Database : HANSEN Search on : PREDISPOSICAO GENETICA PARA DOENCA/ETIOL [Subject descriptor] References found : 22 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18388 Author: Jamieson, S. E; Miller, E. N; Black, G. F; Peacock, C. S; Cordel, H. J; Howson, J. M. M; Shaw, M. A; Burgner, D; Xu, W; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Evidence for cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians ..- Source: s.l; s.n; 2004. 12 p. ilus, tab. Abstract: The region of conserved synteny on mouse chromosome 11/human 17q11-q21 is known to carry a susceptibility gene(s) for intramacrophage pathogens. The region is rich in candidates including NOS2A, CCL2/MCP-1, CCL3/MIP-1x, CCL4/mip-1b, CCL5/RANTES, CCR7, STAT3 and STAT5A/5B. To examine the region in man, we studied 92 multicase tuberculosis (627 individuals) and 72 multicase leprosy (372 individuals) families from Brazil. Multipoint nonparametric analysis (ALLEGRO) using 16 microsatallites shows two peaks of linkage for leprosy at D17S250 (Z score 2.34; P=0.01) and D17S1795 (Z 2.67; P=0.004) and a single peak for tuberculosis at D17S250 (Z 2.04; P=0.02). Combined analysis shows significant linkage genes contribute, 49 informative single nucleotide polymorphisms were typed in candidate genes. Family-based allelic associationtesting that was robust to family clustering demonstrated siginificant associations with tuberculosis susceptibility at four loci separated by intervals (NOS2A-8.4Mb-CCL18-32.3kb-CCL4-6.04 Mb-STAT5B) up to several Mb. Stepwise conditional logistic regression analysis using a case/pseudo-control data set showed that the four genes contributed separate main effects, consistent with a cluster of susceptibility genes across 17q11.2 (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 17/genet CROMOSSOMOS HUMANOS PAR 17/imunol PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/metab MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol MYCOBACTERIUM TUBERCULOSIS/metab - HANSENIASE/genet  TUBERCULOSE/genet  BRASIL/etnol  BRASIL/epidemiol Limits: HUMANO ANIMAL Location: BR191.1; 09314/s

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Id: 18387 Author: Miller, E. N; Jamieson, S. E; Jobert, C; Fakiola, M; Peacock, C. S; Cordell, H. J; Shaw, M. A; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians ..- Source: s.l; s.n; 2004. 5 p. tab, graf. Abstract: Genome-wide scans were conducted for tuberculosis and leprosy per se in Brazil. At stage 1,405 markers (10 cM map) were typed in 16 (178 individuals) tuberculosis and 21 (173 individuals) leprosy families. Nonparametric multipoint analysis detected 8 and 9 chromosomal regions respectively with provisional evidence (P<0.05) for linkage. A stage 2, 58 markers from positive regions were typed in a second set of 22 (176 individuals) tuberculosis families, with 22 additional markers types in all families; 42 positive markers in 50 (192 individuals) new leprosy families, and 30 additional markers in all families. Three regions (10q26.13, 11q12.3, 20p12.1) retained suggestive evidence (peak LOD scores 1.31, 1.78, 1.78; P=0.007, 0.0018, 0.0021) for linkage to tuberculosis, 3 regions (6p21.32, 17q22, 20p13) to leprosy (HLA-DQA, 3.23, P=5.8 x 10-5; D17S1868.2.38, P=0.0005; D20S889, 1.51, P=0.004). The peak at D20S889 for leprosy is 3.5 Mb distal to that reported at D20S115 for leprosy in India (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS HANSENIASE/genet TUBERCULOSE/genet - MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM TUBERCULOSIS/imunol  MYCOBACTERIUM TUBERCULOSIS/metab Location: BR191.1; 09313/s

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Id: 18386 Author: Malhotra, Dheeraj; Relhan, Vineet; Reddy, B. S. N; Bamezai, Ramesh Title: TLR2 Arg677rp polymorphism in leprosy: revisited ..- Source: s.l; s.n; 2005. 3 p. ilus. Abstract: We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogaet TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene. Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol PREDISPOSICAO GENETICA PARA DOENÇA/epidemiol PREDISPOSICAO GENETICA PARA DOENÇA/etiol PREDISPOSICAO GENETICA PARA DOENÇA/genet HANSENIASE/genet HANSENIASE/imunol HANSENIASE/microbiol - COREIA (GEOGRAFICO)/etnol  COREIA (GEOGRAFICO)/epidemiol Limits: HUMANO Location: BR191.1; 09312/s

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17287 Author: Engers, H; Morel, C. M Title: Leprosy ..- Source: s.l; s.n; 2003. 2 p. mapas. Descriptors: Antituberculosos/TU Predisposição Genética para Doença Hanseníase/*/DI/DT/EP/GE Mycobacterium leprae/GE Organização Mundial da Saúde Limits: Humano Location: BR191.1; 00252/s

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Id: 17277 Author: Mohammad, Hatta Title: Epidemiology of leprosy: molecular, biological, and immunological approach ..- Source: s.l; s.n; 2003. 10 p. tab. Abstract: Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU). Descriptors: Anticorpos Análise por Conglomerados DNA Bacteriano Predisposição Genética para Doença/*GE Geografia Incidência Hanseníase/BL/*EP/TM Mycobacterium leprae/GE/*PY Prevalência Estudos Soroepidemiológicos Limits: Humano Location: BR191.1; 09176/s

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Id: 13965 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA LIGACAO (GENETICA) GENOTIPO MYCOBACTERIUM TUBERCULOSIS/patogen TUBERCULOSE/epidemiol TUBERCULOSE/genet FENOTIPO Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09058/s

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Id: 13929 Author: Fitness, J; Tosh, K; Hill, A. V. S Title: Genetics of susceptibility to leprosy ..- Source: s.l; s.n; Dec. 2002. 13 p. tab. Abstract: The ancient disease of leprosy can cause severe disability and disfigurement and is still a major health concern in many parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy sufferers. The outcome of infection is in part due to host genes that influence control of the initial infection and the host's immune response to that infection. Identification of the host genes that influence host susceptibility/resistance will enable a greater understanding of disease pathogenesis. In turn, this should facilitate development of more effective therapeutics and vaccines. So far at least a dozen genes have been implicated in leprosy susceptibility and a genome-wide linkage study has lead to the identification of at least one positional candidate. These findings are reviewed here. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA/genet HANSENIASE/genet HANSENIASE/imunol LIGACAO (GENETICA)/genet LIGACAO (GENETICA)/imunol COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE/genet COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE/imunol Limits: HUMANO ANIMAL Electronic Medium: http://www.ilsl.br Location: BR191.1; 09106/s

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Id: 13659 Author: Mira, M. T; Alcais, A; Pietrantonio, T. di; Thuc, N. V; Phuong, M. C; Abel, L; Schurr, E Title: Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation. (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 6/genet PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO HANSENIASE/clas HANSENIASE/genet ANTIGENOS HLA/genet LIGACAO (GENETICA)/genet FATOR DE NECROSE TUMORAL/genet - FENOTIPO  LINHAGEM Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09137/s

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Id: 13653 Author: Lee, Seong-Beom; Kim, Byoung Chul; Jin, Song Hou; Park, Yong-Gyu; Kim, Se-Kom; Kang, Tae-Jin; Chae, Gue-Tae Title: Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea ..- Source: s.l; s.n; 2003. 5 p. tab. Abstract: Interleukin-12 receptor beta 1 ( IL12RB1), interleukin-12 receptor beta 2 ( IL12RB2), and interferon gamma receptor 1 ( IFNGR1) perform important roles in the host defense against intracellular pathogens such as Mycobacteria. Several mutations within their genes have been confirmed as associated with increased susceptibility to mycobacterial infection. However, the association between mutations of the IL12RB1, IL12RB2, and IFNGR1 encoding genes and lepromatous leprosy has not been studied. This study screened for polymorphisms within IL12RB1, IL12RB2, and IFNGR1 encoding genes in the Korean populations using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP) DNA sequencing assay, and an association study was performed using the missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), and 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14M), and 1443 T/C (L467P) for the IFNGR1 encoding genes. There were no differences in the genotype and allele frequencies of IL12RB1 and IFNGR1 genes between 93 lepromatous leprosy patients and 94 control subjects. In conclusion, missense mutations of 705 A/G (Q214R), 1196 G/C (G378R), 1637 G/A (A525T), 1664 C/T (P534S) of the IL12RB1, 83 G/A (V14 M), and 1443 T/C (L467P) of the IFNGR1 encoding genes have no association with the susceptibility to lepromatous leprosy in the Korean population. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA COREIA (GEOGRAFICO) HANSENIASE VIRCHOWIANA/etiol HANSENIASE VIRCHOWIANA/genet MUTACAO DE SENTIDO INCORRETO RECEPTORES DE INTERFERON/genet RECEPTORES DA INTERLEUCINA/genet Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 09125/s

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Id: 13638 Author: Plancoulaine, S; Alcaïs, A; Abel, L; Casanova, J. L Title: Infections mycobactériennes humaines: im´pact des facteurs génetiques de l'hôte Human mycobacterial infections: impact of host genetic factors- Source: s.l; s.n; 2002. 6 p. ilus. Abstract: Humans are exposed worldwide to a variety of environmental mycobacteria (EM) and most children are inoculated with live Bacille Calmette-Guérin (BCG) vaccine. Although rarely pathogenic, poorly virulent mycobacteria, including BCG and most EM, may cause a variety of clinical diseases. M. tuberculosis and M. leprae are more virulent, causing tuberculosis, and leprosy, respectively. Remarkably, only a minority of individuals develop clinical disease, even if infected with virulent mycobacteria. There is now accumulating evidence that the large interindividual variability of clinical outcome results in part from variability in the human genes that control host defense. We review here in current knowledge about genetic predisposition to common (leprosy and tuberculosis) and rare (BCG and EM infections) mycobacterial infections. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA HANSENIASE/etiol HANSENIASE/genet MYCOBACTERIUM/patogen MICOBACTERIOSE/etiol MICOBACTERIOSE/genet TUBERCULOSE PULMONAR/etiol TUBERCULOSE PULMONAR/genet VARIACAO (GENETICA) Limits: HUMANO RESUMO EM INGLES Electronic Medium: http://www.ilsl.br Location: BR191.1; 09052/s

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Id: 13635 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease.(AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO LIGACAO (GENETICA) MYCOBACTERIUM TUBERCULOSIS/patogen FENOTIPO TUBERCULOSE/epidemiol TUBERCULOSE/genet Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09044/s

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Id: 13627 Author: Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M; Hill, Adrian V. S Title: A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population ..- Source: s.l; s.n; 2002. 4 p. tab, graf. Abstract: A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. (AU). Descriptors: MAPEAMENTO CROMOSSÔMICO CROMOSSOMOS HUMANOS PAR 20/genet MARCADORES GENETICOS/genet PREDISPOSICAO GENETICA PARA DOENÇA/genet GENETICA POPULACIONAL HANSENIASE/genet REPETICOES DE MICROSSATELITES/genet MYCOBACTERIUM LEPRAE INDIA Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08997/s

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Id: 13622 Author: Hegazy, Aly A; Abdel-Hamid, Ibrahim A; Ahmed, El-Shahat F; Hammad, Sabry M; Hawas, Samia A Title: Leprosy in a high-prevalence Egyptian village: epidemiology and risk factors ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Abstract: BACKGROUND: The epidemiology of leprosy in rural Egypt is unknown. This prospective household survey was conducted in a high-prevalence Egyptian village in order to explore the epidemiologic characteristics of the disease and to determine the possible socioeconomic and HLA genotype risk factors. METHODS: The subjects of the study were the residents of Kafr-Tambul village in the Dakahlia governorate, Egypt. There were 10,503 inhabitants of the village, of whom 9643 (91.8 per cent) had a complete visual skin examination, and suspected leprosy patients were subjected to histopathological examination and slit skin smears. Each household was interviewed to record personal data on family members, family size, education, occupation, crowding index at sleep, social score and source of water supply. Human leukocyte antigen (HLA) class II genotypes were analyzed in all leprosy patients and in a number of both household (N = 124) and non-household (N = 30) contacts. RESULTS: The overall prevalence of clinical leprosy in the village studied was 24.9/10,000 (95 per cent CI = 16.3-37.6). Individuals above the age of 40 years were 4 times more likely to develop leprosy (OR = 4, P= 0.01). The degree of education, crowding index at sleep, social score and source of water supply were found to be unlikely to increase the risk of leprosy (P > 0.05). The frequencies of HLA-DR2 and -DQ1 were significantly associated with leprosy (OR = 3.33 and 5.4; CI = 0.95-12.07 and 1.08-30.19, respectively, all P < 0.05). CONCLUSIONS: Our study provides the first picture of the epidemiology of leprosy in a high-prevalence village in rural Egypt. Leprosy detection campaigns should be initiated and directed towards high-prevalence villages. Provision of leprosy control activities in rural health units is necessary in order to detect new cases. The risk for leprosy is associated with HLA-DR2 and -DQ1 markers, and these markers appear to increase personal susceptibility to leprosy in this village. (AU). Descriptors: FATORES ETARIOS EGITO/epidemiol PREDISPOSICAO GENETICA PARA DOENÇA/genet GENOTIPO ANTIGENOS HLA/genet LEVANTAMENTOS EPIDEMIOLOGICOS HANSENIASE/epidemiol HANSENIASE/etiol HANSENIASE/genet PREVALÊNCIA ESTUDOS PROSPECTIVOS FATORES DE RISCO POPULACAO RURAL/estatíst FATORES SOCIOECONÔMICOS Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09012/s

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Id: 13533 Author: Cooke, Graham S; Hill, Adrian V. S Title: Genetics of susceptibility to human infectious disease ..- Source: s.l; s.n; 2001. 11 p. ilus, tab. Abstract: Before Robert Koch's work in the late nineteenth century, diseases such as tuberculosis and leprosy were widely believed to be inherited disorders. Heritability of susceptibility to several infectious diseases has been confirmed by studies in the twentieth century. Infectious diseases, old and new, continue to be an important cause of mortality worldwide. A greater understanding of disease processes is needed if more effective therapies and more useful vaccines are to be produced. As part of this effort, developments in genetics have allowed a more systematic study of the impact that the human genome and infectious disease have on each other. (AU). Descriptors: DOENCAS TRANSMISSIVEIS/genet EVOLUCAO PREDISPOSICAO GENETICA PARA DOENÇA ANTIGENOS HLA/genet LIGACAO (GENETICA) Limits: HUMANO Location: BR191.1; 08979/s

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Id: 12295 Author: Meisner, Sarah J; Mucklow, Stuart; Warner, Giles; Sow, Samba O; Lienhardt, Christian; Hill, Adrian V. S Title: Association of NRAMP1 polymorphism with leprosy type but not susceptibility to leprosy per se in West Africans ..- Source: s.l; s.n; 2001. 3 p. tab. Descriptors: ESTUDOS DE CASOS E CONTROLES GENOTIPO HANSENIASE HANSENIASE MALI RAÇA NEGRA POLIMORFISMO (GENÉTICA) PROTEINAS TRANSPORTADORAS DE CATIONS/*GE PREDISPOSICAO GENETICA PARA DOENCA/*GE Location: BR191.1; 08664/s

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Id: 11600 Author: Marquet, Sandrine; Schurr, Erwin Title: Genetics of susceptibility to infectious diseases: tuberculosis and leprosy as examples ..- Source: s.l; s.n; 2001. 5 p. tab. Descriptors: MODELOS ANIMAIS DE DOENÇAS HANSENIASE CAMUNDONGOS TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/* Limits: ANIMAL Location: BR191.1; 08419/s

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Id: 11455 Author: Skamene, Emil; Schurr, Erwin; Gros, Philippe Title: Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections ..- Source: s.l; s.n; 1998. 13 p. . Descriptors: ALELOS ANTITUBERCULOSOS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS PROTEINAS DE TRANSPORTE SURTOS DE DOENÇAS SUSCETIBILIDADE A DOENÇA GENOMA BACTERIANO GENOMA HUMANO GENOMA DE PROTOZOARIO LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) MACROFAGOS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS INFECÇOES POR SALMONELLA INFECÇOES POR SALMONELLA TUBERCULOSE TUBERCULOSE TUBERCULOSE TUBERCULOSE Predisposição Genética para Doença Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 08338/s

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Id: 11442 Author: Buu, N; Sánchez, F; Schurr, E Title: The Bcg host-resistance gene ..- Source: s.l; s.n; 2000. 5 p. graf. Descriptors: VACINA BCG NEOPLASIAS DA BEXIGA NEOPLASIAS DA BEXIGA NEOPLASIAS DA BEXIGA PROTEINAS DE TRANSPORTE PROTEINAS DE TRANSPORTE MARCADORES GENÉTICOS IMUNIDADE NATURAL HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) PROTEINAS DA MEMBRANA PROTEINAS DA MEMBRANA CAMUNDONGOS TUBERCULOSE PULMONAR TUBERCULOSE PULMONAR PREDISPOSICAO GENETICA PARA DOENCA Limits: ANIMAL Location: BR191.1; 08324/s

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Id: 10357 Author: Levin, Michael; Newport, Melanie Title: Understanding the genetic basis of susceptibility to mycobacterial infection ..- Source: s.l; s.n; 1999. 5 p. . Descriptors: CRIANÇA GAMBIA IMUNIDADE NATURAL HANSENIASE MALTA CAMUNDONGOS MICOBACTERIOSE RECEPTORES DE INTERFERON TUBERCULOSE PREDISPOSICAO GENETICA PARA DOENCA/*GE Location: BR191.1; 07474/s

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